MSI Press Blog

  When Angelina Jolie shared that she carries a BRCA1 mutation and chose a preventive double mastectomy, she did more than tell her story—she shifted the behavior of thousands of women worldwide. Rates of risk‑reducing mastectomy rose sharply after her announcement, especially among women with BRCA1 or BRCA2 mutations, who can face a lifetime breast cancer risk of 60–70% or more. The “Angelina Jolie effect” is real: more women are getting tested, more are offered options, and more are choosing aggressive surgery to lower their risk. For many, that surgery does exactly what it promises: it dramatically reduces the chance of developing breast cancer. Studies show that bilateral risk‑reducing mastectomy in BRCA1/2 carriers can cut breast cancer incidence by about 90% or more. For some women, that reduction in risk feels like the difference between living under a constant shadow and finally being able to exhale. But there’s another part of the story that doesn’t fit neatly into he...

  For years, alcohol carried a kind of health halo — especially red wine. But modern cancer research has stripped away the romance and left us with a clear, uncomfortable truth: alcohol is a carcinogen , full stop. Not just hard liquor. Not just “heavy drinking.” Any drink containing ethanol — beer, wine, cocktails — increases cancer risk. Why alcohol raises cancer risk When the body breaks down alcohol, it produces acetaldehyde , a toxic compound that: damages DNA interferes with DNA repair promotes inflammation disrupts hormone regulation (especially estrogen) Over time, these changes increase the likelihood that damaged cells will become cancerous. Which cancers are linked to alcohol? The list is longer than most people realize. Strong evidence connects alcohol to: Breast cancer (even at low levels) Colorectal cancer Liver cancer Esophageal cancer Head and neck cancers Stomach cancer (emerging evidence) There is no safe threshold . Even one drink a day nudges...

  Hypercalcemia is a serious but treatable complication of cancer. It occurs when calcium levels in the blood rise too high, often signaling advanced disease. Recognizing its symptoms and understanding its causes can help patients and caregivers respond quickly. 🩺 What is Hypercalcemia? Hypercalcemia means higher-than-normal calcium levels in the blood . Calcium is essential for strong bones, muscle movement, nerve signaling, and heart rhythm. But when levels climb too high, the body’s systems are disrupted, leading to dangerous complications. 🎯 Which Cancers Are Linked to Hypercalcemia? Hypercalcemia is most often seen in advanced cancers . The cancers most commonly associated include: Breast cancer Bone cancer Lung cancer Kidney cancer Prostate cancer Multiple myeloma Leukemia and lymphoma Head and neck cancers Gastrointestinal cancers 🔬 How Does It Happen? Cancer can cause hypercalcemia through several mechanisms: Bone metastases : Tumors spread to bone, re...

  Probably, most people would not connect sleep deprivation and cancer, but some new research indicates there might be a connection. There appears to be as well a connection between sleep deprivation and obesity and between obesity and certain kinds of cancer.  According to various research projects, long-term sleep deprivation can affect the body's biological clock, which controls sleep and other functions, potentially raising the odds of cancers such as breast, colon, ovarian, and prostate. Night owls can be particularly at risk. Exposure to light during overnight shifts for several years can reduce levels of melatonin, a hormone that helps regulate sleep and may also have a role in preventing cancer growth. Here are a couple of the websites:  Does Sleep Affect Cancer Risk? | American Cancer Society  and  How does being a night owl impact quality of life and why? . For other Cancer Diary posts, click  HERE . Blog editor's note: As a memorial to Carl, and ...