MSI Press Blog

  Hypercalcemia is a serious but treatable complication of cancer. It occurs when calcium levels in the blood rise too high, often signaling advanced disease. Recognizing its symptoms and understanding its causes can help patients and caregivers respond quickly. 🩺 What is Hypercalcemia? Hypercalcemia means higher-than-normal calcium levels in the blood . Calcium is essential for strong bones, muscle movement, nerve signaling, and heart rhythm. But when levels climb too high, the body’s systems are disrupted, leading to dangerous complications. 🎯 Which Cancers Are Linked to Hypercalcemia? Hypercalcemia is most often seen in advanced cancers . The cancers most commonly associated include: Breast cancer Bone cancer Lung cancer Kidney cancer Prostate cancer Multiple myeloma Leukemia and lymphoma Head and neck cancers Gastrointestinal cancers 🔬 How Does It Happen? Cancer can cause hypercalcemia through several mechanisms: Bone metastases : Tumors spread to bone, re...

  For Carl, hypercalcemia didn’t just show up in lab results—it appeared as brain fog, confusion, and instability . He fell several times, a common outcome when calcium disrupts muscle and nerve function. These symptoms led him to the ER repeatedly, where doctors gave him IV infusions to quickly lower calcium levels. 💉 What’s in the ER Shots or Infusions? According to clinical guidelines, ER treatment for hypercalcemia of malignancy typically includes: IV fluids (saline) : The first step, flushing calcium through the kidneys. Bisphosphonates (pamidronate, zoledronic acid) : IV drugs that block bone breakdown and reduce calcium release. Denosumab : A targeted antibody used when bisphosphonates aren’t enough. Calcitonin injections : Fast-acting hormone therapy that lowers calcium within hours, though only short-term. Steroids : Sometimes used in lymphoma-related hypercalcemia. Dialysis : Reserved for severe cases with kidney failure. Carl received IV bisphosphonates/deno...

  🦴 How Bone Cancer Triggers Hypercalcemia Hypercalcemia in cancer is often caused by bone metastases —when cancer cells invade bone tissue and stimulate osteoclasts , the cells that break down bone. This breakdown releases calcium stored in the bones into the blood. The more aggressive or widespread the bone involvement, the higher the risk. There are two main pathways: Direct bone destruction : Seen in cancers like multiple myeloma, breast, lung, and prostate cancer that metastasize to bone. Paraneoplastic hormone production : Some tumors produce parathyroid hormone–related peptide (PTHrP) or excess calcitriol (vitamin D) , which also increase calcium levels. 🧬 Cancers Most Likely to Cause Hypercalcemia via Bone Involvement Multiple myeloma : Directly affects bone marrow and causes extensive bone breakdown. Breast cancer : Frequently metastasizes to bone. Lung cancer : Can cause hypercalcemia through both bone metastases and PTHrP production. Prostate cancer : Often...

  from treatment and recovery systems Many of the decisions that that Carl made in the last few months of his cancer-riddled life were completely irrational. In some cases, I did not know enough about the situations to know that they were irrational; they did not seem right, but the contractors went along with Carl. After all, he was paying, so it was his decision even if irrational.  Examples?  He had the sump pump behind the house removed and the area filled with concrete. During the first tremendous rains -- California's 2023 crazy storm season -- we ended up with a backyard swimming pool. The plumber reinstalled the sump pump.  He set up three generators (one probably would have done) powered by a wind turbine (we do have a lot of wind here) to maintain electricity if the power went out for a long period of time. Yes, we are on top of an earthquake fault, but we had not lost power for more than a couple of hours -- ever. And have not lost it at all since. To powe...

  Today would have been the 54th anniversary for Carl  and me. Last year, I spent it in the cemetery with Carl, as I did the year before. This year I cannot because I am in Bandung, Indonesia, but perhaps that is just as well.  On our 51st, he was alive, but not well. Three weeks earlier, he had fallen, been xrayed, and found to be in the advanced stage of cancer of unknown primary , with liver, lungs, bones, and stomach completely riddled with cancer cells, blood clots in his lungs, and his bones throwing off cells to create hypercalcemia, the reason he had fallen. It was a difficult time. We were just coming out of the covid months. We brought our CHARGE Syndrome son CB who had been living in group homes for 20 years home when they were not careful with protection from covid. At the same time, our spina bifida daughter, who lives about 30 miles to the south of us, independently, with a county-provided part-time aide lost her caregiver to surgery and no one wanted to tak...