🧠Gender-Based Differences in Brain Aging
Women’s longer lifespan but greater late‑life frailty isn’t a contradiction — it’s a biological, hormonal, and inflammatory pattern that shows up across multiple aging datasets. The research you’re drawing from captures what gerontologists now call the sex‑frailty paradox : women age slower at the molecular level yet experience more functional decline in very old age. Here’s a deeper, structured expansion grounded in current research. 🧩 Core paradox Women show lower biological ages on multi‑omic aging clocks across organs — meaning their tissues accumulate damage more slowly. Yet women are more frail and have worse functional health at the end of life, while men often perform better on physical function tests (grip strength, gait speed) in old age. This pattern is robust across cohorts and appears in both molecular biomarkers and clinical frailty indices. 🧬 1. Biological aging vs. functional aging Recent multi‑organ aging‑clock research shows women’s tissues — cardiovasc...